VWF and Thrombocytopenia: From a pathophysiological perspective, the clinical profile of the patient group—characterized by severe thrombocytopenia, hemolytic anemia, and marked increases in LDH, reflects heightened microthrombotic activity, in which vWF multimers promote platelet aggregation by binding to glycoprotein Ib, thereby accelerating intravascular hemolysis and platelet consumption.