Several X-chromosomal CpGs (e.g., in PQBP1, ZNF41, RPL10) and one on chr6 (TAP2) lower methylation in BPD. Hypomethylation differences were amplified in BPD subjects with childhood trauma. Additionally, four autosomal genes (e.g., POU5F1, GGT6) were differentially methylated depending on trauma history. The gene discussed is PQBP1; the disease is Borderline personality disorder.