BMD: A small placebo-controlled RCT that included four patients with stage 4 CKD and six patients on hemodialysis found cinacalcet to increase proximal femur BMD (0.945 to 0.961 g/cm2; p < 0.05) without an effect on lumbar spine; BMD change correlated with PTH reduction (R2 = 0.39; p < 0.05) [71]. The gene discussed is PTH; the disease is chronic kidney disease.