A prospective controlled cohort investigated long-term effects in 46 KTRs (males and females) with osteoporosis (median FRAX 10-year fracture risk 16% [10.4, 21.1]), good allograft function (creatinine 115.8 [39.8] μmol/L), and controlled CKD-MBD parameters (PTH 123.5 [96.0] pg/mL, corrected calcium 2.4 [0.125] mmol/L, alkaline phosphatase 83.4 U/L [43.5]). This evidence concerns the gene PTH and osteoporosis.