Although clinical evaluation primarily depends on albuminuria and estimated glomerular filtration rate (eGFR), a considerable subset of individuals with T2DM develop kidney damage without increased urinary albumin (non-albuminuric DN) [4,5]; thus, albuminuria may be absent even in histologically confirmed disease, and a decline in eGFR usually only appears after appreciable nephron loss [6,7]. The gene discussed is ALB; the disease is Nephropathy.