SIRT2 and type 2 diabetes mellitus: Multinomial logistic regression analyses adjusted for age, sex, and BMI showed that serum SIRT2 was an independent predictor most pronounced in the nephropathy group (T2DM + N: β = 0.20, OR = 1.222, 95% CI 1.109–1.346, p < 0.001) and also in patients with type 2 diabetes without nephropathy (T2DM − N: β = 0.13, OR = 1.143, 95% CI 1.039–1.258, p = 0.006); as shown in the forest plot (Figure 4), the SIRT2 odds ratios and their 95% confidence intervals lie entirely to the right of the OR = 1 reference line in both comparisons, indicating a statistically significant positive association.