After adjustment for age, sex, and body mass index, each 1-SD increase in SIRT2 was associated with a 2.21-fold higher odds of diabetes without nephropathy compared with controls (OR = 2.205; 95% CI: 1.40–5.60; Hosmer–Lemeshow χ2 = 13.871, p = 0.085), while in the diabetic nephropathy group this increase was approximately 36.41-fold (OR = 36.413; 95% CI: 7.53–7205.02; Hosmer–Lemeshow χ2 = 7.631, p = 0.470). This evidence concerns the gene SIRT2 and diabetic kidney disease.