Median serum SIRT2 levels were 6.13 ng/mL in healthy controls, 8.53 ng/mL in the T2DM − N group, 9.89 ng/mL in the microalbuminuria group, and 33.19 ng/mL in the macroalbuminuria group, with significant differences across groups (p < 0.001) (Table 3). Here, SIRT2 is linked to type 2 diabetes mellitus.