CCL2 and Keratoconjunctivitis sicca: As MCP-1 is produced as a response to inflammatory stimuli [38], eyes with higher MCP-1 tear levels may result from any use of glaucoma medications [8], a longer duration of glaucoma medications [8], the presence of inflamed ocular surfaces [38], moderate-to-severe dry eyes [33], or significant meibomian gland disease [39].