Molecular alterations in IBD-CRC include early TP53 mutations, DNA aneuploidy, and less frequent APC and KRAS mutations, in contrast to sCRC, where APC loss is typically the initiating event, followed by KRAS activation, chromosomal instability (CIN), and late TP53 loss [7,8,9,10]. Here, APC is linked to cervical squamous intraepithelial neoplasia.