The prevalence of germline DDX41 variants varied by disease: 6.2% (13/210) in AML, 11.1% (15/135) in MDS, 2.4% (2/82) in CML, 0.5% (1/204) in Ph-negative MPN, 33.3% (1/3) in MPAL, and 2.0% (1/50) in ALL (Figure 1A). Here, DDX41 is linked to acute myeloid leukemia.