Additionally, damage caused by sequential ischemia and reflow leads to endoplasmic reticulum (ER) stress in the decidua and placentas from pregnancies complicated by preeclampsia or fetal growth restriction, resulting in apoptosis of the decidua and cytotrophoblast cells, as well as reduced transcription of placental growth factor, a key proangiogenic factor essential for normal pregnancy development [78,79,80,81]. The gene discussed is PGF; the disease is preeclampsia.