PGF and preeclampsia: Abnormal remodeling of spiral arteries, placental hypoperfusion, and vascular endothelial dysfunction occurring in preeclampsia lead to an imbalance of circulating proangiogenic and antiangiogenic factors, especially placental growth factor (PlGF) and sFlt-1, which leads to an increase in the sFlt-1/PlGF ratio [64,65,66].