IL1B and Hyperglycemia: Priming through TLR2/4 or RAGE engagement by oxidized LDL and other damage-associated molecular patterns induces NLRP3 and pro-IL-1β transcription, while activation by cholesterol crystals, ATP-P2X7-mediated potassium efflux, mitochondrial ROS or DNA release, hyperglycemia, or ischemia–reperfusion triggers caspase-1, producing IL-1β and IL-18 [16,20].