The transient receptor potential (TRP) channels, particularly TRPV1 (activated above 43 °C) and TRPV4 (responding to 24–35 °C), play a key role in migraine development by triggering inflammation and releasing pro-inflammatory agents like calcitonin gene-related peptide (CGRP) and substance p [53,54]. The gene discussed is TAC1; the disease is migraine disorder.