Recently, it was reported that a 1,2,5-thiadiazolidine derivative, ABBV-CLS-484 (AC484), able to potently inhibit both TCPTP and PTP1B at very low nanomolar concentrations, amplifies responsiveness of tumor cells to IFNγ, promotes T cell activation and impairs tumor growth in mice [103]. The gene discussed is PTPN2; the disease is neoplasm.