SHP2-D26 was shown to induce SHP2 degradation in both esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cell lines, in a rapid and dose-dependent manner, with DC50 values (concentration required to induce 50% degradation of the targeted protein) of 6.0 nM and 2.6 nM, respectively [61]. Here, PTPN11 is linked to esophageal cancer.