Brain tissue from PD, DLB patients, and controls examined; B103 neuroblastoma cells producing alpha-synuclein treated with adiponectin; transgenic mice expressing wild-type human alpha-synuclein treated with gAPN every 3 days for 2 months; 5-month-old mice also treated with i.n. gAPN. This evidence concerns the gene SNCA and Parkinson disease.