PTGS2 and Stroke: A decrease in inflammatory mediators, including the expression of NF-κB target genes such as ICAM-1, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), was also observed in the mouse model of experimental stroke [97].