Furthermore, it has been demonstrated that in a rat model of type 2 diabetes, supplementation with GFP resulted in a statistically significant decrease in IL-1β, TNFα, Monocyte Chemoattractant Protein-1 (MCP-1), and TLR4, accompanied by an increase in IL-10 and AMP-activated protein kinase (AMPK) in the liver [108]. This evidence concerns the gene CCL2 and type 2 diabetes mellitus.