In HFD-fed mice, lentinan reduced hepatic inflammation and glucose intolerance by suppressing NF-κB activation and Protein Tyrosine Phosphatase 1B (Ptp1b) expression, thereby restoring insulin signaling via the Akt–glycogen synthase kinase 3 beta (GSK3β) cascade. The gene discussed is PTPN1; the disease is Glucose intolerance.