Their key metabolites, namely ellagic acid and urolithins, execute these effects by reducing oxidative stress, modulating cellular signaling networks involved in tumor survival (PI3K/Akt, MAPK/ERK, Wnt/β-catenin and NF-κB), as well as direct regulation of apoptosis-related proteins (Bcl-XL, Bax, caspases, PARP) and EMT/migration markers (GOLPH3, MMP-2, MMP-9, N-cadherin, E-cadherin, TIMPs, Snail, Slug). The gene discussed is MAPK1; the disease is neoplasm.