Collectively, these indices represent interconnected inflammatory and metabolic pathways associated with obesity, with SII, NLR, PLR, and MLR reflecting systemic immune activation, CRP/Alb indicating inflammation–nutrition balance, and FIB-4, TG/HDL, and TG/Glucose ratios capturing hepatic and metabolic dysfunction. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.