Airborne pollen can cause immediate reactions, i.e., IgE-mediated type I hypersensitivity, which occur in two phases, sensitisation and effector, in patients with respiratory allergic diseases such as allergic rhinitis, allergic rhinoconjunctivitis and asthma, as well as other conditions such as atopic dermatitis, acute urticaria/angioedema, and allergies to food, insect venom and medicines [4,5]. This evidence concerns the gene IGHE and allergic disease.