After adjusting for known cardiovascular and PAD risk factors, the association between IL-27 Q4 and MACE remained statistically significant (HR 2.95, 95% CI 1.06–8.22, p = 0.039); however, the association between IL-27 and MALE was attenuated and no longer statistically significant (HR 0.97, 95% CI 0.56–1.70, p = 0.926). The gene discussed is IL27; the disease is peripheral arterial disease.