Indeed, three well validated autosomal dominant genes (SNCA, LRRK2, and VPS35) and three well validated autosomal recessive genes PRKN, PINK1, and DJ1 are known to cause Parkinson’s disease [173,175], inducing defects in mitochondria, axonal transport, and the dopaminergic system [176,177]. This evidence concerns the gene PRKN and Parkinson disease.