It was initiated in 73 cases presenting with severe bleeding symptoms of ITP (4 cases with moderate thrombocytopenia with platelets < 35,000/mm3, and 69 cases with severe thrombocytopenia), as follows: platelet concentrate in 3 cases, steroids in 38 cases, intravenous human immunoglobulin alone in 11 cases and in combination with steroids in 5 cases, and thrombopoietin receptor agonists (TPO-RAs) have been used in 16 cases (Table 9). This evidence concerns the gene MPL and Thrombocytopenia.