WRN and Werner syndrome: Progeroid syndromes provide further examples: in Dyskeratosis Congenita, mutations in telomerase or shelterin components cause telomere attrition in alveolar progenitors, leading to pulmonary fibrosis [208] and in Werner syndrome, loss of the WRN helicase accelerates interstitial lung disease and fibrosis, underscoring how DNA repair failure destabilizes lung homeostasis [209] (Figure 7).