SLC2A4 and Insulin resistance: RSV improves glycemic control and insulin resistance in DM by enhancing glucose uptake, promoting GLUT4 expression and translocation, and activating the NAD+-dependent histone deacetylase Silent Information Regulator 1 (Sirtuin1), which inhibits Forkhead transcription factor O1 (FOXO1) expression, exerting protective effects on mitochondrial dysfunction, one of the main drivers of T2DM [50,51].