VWF and type 2 diabetes mellitus: In T2DM, there is suppression of anticoagulant molecules, such as thrombomodulin, and impaired fibrinolysis, resulting in increased levels of circulating pro-inflammatory cytokines (TNF-α, IL-1, IL-6), pro-coagulant factors (von Willebrand factor, VWF), plasma fibrinogen, and thrombin [11].