Hemangioblastomas are usually positive for alpha-inhibin, D2-40, brachyury, NSE, NCAM1, S100, ezrin, CXCR4, aquaporin-1, and occasionally for GFAP and EGFR, and negative for EMA, CD10 and CAM5.2 [22]. This evidence concerns the gene PDPN and hemangioblastoma.