NGF and neoplasm: In another study published the following year, the same authors, starting from the assumption that angiogenesis plays a critical role in the development of OSA and its metastases, demonstrated, through an in vitro study on human OSA cells, that the NGF-TrkA axis promotes angiogenesis mediated by platelet-derived growth factor (PDGF) through the suppression of microRNA-29b-3p, and, again, that larotrectinib effectively reduces the migration and invasion capabilities of tumor cells in a dose-dependent manner [51].