For example, composite cell sheets from rat PDLSCs and mice-osteoblast-like cells were found to promote mice periodontitis treatment through the formation of PDL-like fibers and AB periodontal ligament structures; this finding was determined based on immunohistochemical (IHC) analyses for the expression of periostin and osteocalcin (OCN) and azan staining for PDL-like fibers [57]. Here, BGLAP is linked to periodontitis.