NPM1 and acute myeloid leukemia: KEGG enrichment analysis revealed that the cell cycle pathway was significantly enriched in two t(8;21) AML samples (p = 0.0015 and 0.018), one inv(16) AML sample (p < 0.001), and one FLT3-ITD+ NPM1+ sample (p < 0.001) (Figure 4A).