In depression mice, GC levels elevate, Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) expression in bone marrow mononuclear cells show upregulated, as well as intima-media thickness, HR, plasma cholesterol, triglycerides, and low-density lipoprotein (LDL)-to-HDL ratios are increased. The gene discussed is TLR4; the disease is depressive disorder.