Elevated levels of high-sensitivity CRP (hs-CRP) in patients undergoing percutaneous coronary intervention (PCI), NOD-like receptor thermal protein domain associated protein 3 (NLRP3) in patients with ST-segment elevation myocardial infarction (STEMI), and TNF-α and IL-17A in CHD patients have all been associated with depression [123,124,125]. The gene discussed is TNF; the disease is major depressive disorder.