IL6 and coronary artery disorder: Probiotic Probio-M8 improves Seattle Angina Questionnaire scores and anxiety-depressed symptoms in patients with CAD, reduces serum IL-6 and low-density lipoprotein cholesterol levels, alters gut microbiota composition, and highlights changes in microbial bioactive metabolites, including increased methyl xanthine and decreased pro-atherogenic compounds [209].