size and weight of adipose deposits in epididymal adipose tissue/hepatic steatosis was reduced/GeneChip profiling of the liver transcriptome revealed potential activity on stimulating autophagy and regulating mitochondrial function/activity and migration of dynamin-related protein 1 (Drp1) by regulating the orphan nuclear receptor subfamily 4 group A member, thereby attenuating the excessive mitochondrial fission induced by high glucose and fatty acid load. The gene discussed is DNM1L; the disease is fatty liver disease.