Increased methylation in individuals with familial ovarian cancer compared to sporadic cancer [54]Increased methylation is associated with higher probability of PARP inhibitor efficacy [55]Methylation of Fanconi-anemia gene, which may interact with BRCA leads to cisplatin resistance [56]Hypermethylation of BRCA1 is more frequent in serous than endometrioid ovarian cancer [57]Bilateral ovarian cancer displays higher levels of BRCA1 methylation [58,59]. Here, BRCA1 is linked to familial ovarian cancer.