Additionally, cyclin D1 (CCND1; chr 11q), fibroblast growth factor receptor 3 (FGFR3; chr 4p), and PIK3CA (chr 3q) were amplified in the tumor tissues from patients S390 and S425, S425 and S028, and S425 and S424, respectively. This evidence concerns the gene PIK3CA and neoplasm.