A current experimental study employing adult A53T mice reported that treadmill exercise and fenofibrate decreased α-synuclein aggregation in nigral neurons and promoted its clearance via PPARα activation, which upregulated lysosomal biogenesis, known for its determinant role in the clearance of the misfolded α-synuclein that drives neurodegeneration in PD and related NDs. This evidence concerns the gene PPARA and Parkinson disease.