To evaluate the diagnostic value of Mendelian randomisation-prioritised genes (hereafter, risk genes), the discriminative capacity of each gene was assessed using univariate ROC analysis, and the combined effect of all genes was assessed using a LASSO logistic regression model in two independent transcriptomic datasets: GBA1-associated PD (N370S/+) and sporadic PD. This evidence concerns the gene GBA1 and Parkinson disease.