PRKDC and immunodeficiency disease: Specific strains of mice, such as BALB/c nude, non-obese diabetic severe combined immunodeficiency (NOD-SCID), and NOD-Prkdc scid IL2rg null (NCG) mice, are ideal candidates for xenograft studies because their immunodeficiency and other immune system features prevent the rejection of implanted human cancer cells or tissues.