CREBBP and diffuse large B-cell lymphoma: This finding aligns with the known epidemiology of DLBCL, in which incidence increases with age, and older patients often present with more complex genetic profiles, potentially due to cumulative genetic instability over time- or age-related oncogenic pathways involving epigenetic changes or mutations in genes such as CREBBP, EZH2, and KMT2D [22].