Current smoking (OR = 1.76, 95% CI [1.26–2.45], p = 0.001), elevated CRP (1–3 mg/L: OR = 1.40, 95% CI [1.04–1.87], p = 0.026; ≥3 mg/L: OR = 1.63, 95% CI [1.00–2.66], p = 0.033), and obesity (OR = 8.29, 95% CI [6.12–11.21], p < 0.001) significantly increased the likelihood of CMRC. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.