In survey-weighted multivariable models, sufficient vitamin D (≥20 ng/mL) was associated with lower odds of CMRC, whereas elevated CRP (≥1.0 mg/L), obesity, and current smoking were associated with higher odds; meeting the WHO physical activity guideline was protective, while education, income, alcohol use, and sleep duration were not significant after adjustment. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.