In NUP98-NSD1-positive AML, the fusion protein associates with SMARCA5, a member of the ISWI family of ATP-dependent chromatin remodeler, and its co-dependent partners BPTF and NUP188; catalytically active SMARCA5 is required for NUP98-NSD1-mediated hematopoietic transformation [104]. This evidence concerns the gene NSD1 and acute myeloid leukemia.