While translocations involving NUP98 were initially believed to occur with relatively low frequency, re-evaluation of cytogenetically normal (CN)-AML cases revealed that NUP98-NSD1 fusion represents approximately 16% and 2.3% of pediatric and adult cases, indicating frequent misclassification by routine karyotyping and a higher incidence in pediatric AML [15]. This evidence concerns the gene NUP98 and acute myeloid leukemia.