In t(4;14) multiple myeloma, NSD2 overexpression promotes PKCα-driven metabolic processes that increases HK2 expression [138], or disrupts the synthesis of creatine by diverting SAM to global H3K36me2, thereby creating higher dependence on adenylate kinase 2 (AK2), a mitochondrial enzyme catalyzing the transfer of high-energy phosphate [139]. Here, NSD2 is linked to plasma cell myeloma.