IL6 and neoplasm: However, lymphocytes and exclusively activated T-cells cannot infiltrate the tumor core properly [79] due to some TME elements such as myeloid-derived suppressing cells (MDSCs) [80], Extracellular matrix [81], Tumor-associated stroma [82], cancer-associated fibroblasts (CAFs) [83], and increased inhibitory cytokines such as TGF-β, IL-6, and IL-10 [84] (Figure 1).