IFNG and neoplasm: In these cases, other factors that boost anti-tumor immunity in TME, such as the M1 macrophages [70], Th1 cells [71], an increase in anti-tumor cytokines like IFN-γ and granzyme B (GzmB) [72,73,74], increased CXCL9/10 chemokines which correlate with lymphocyte infiltration [75], contribute to an overall better immune response (Figure 1).