Taken together, in our study, these results underscore the compartment-specific dysregulation of TGF-β1: diminished intimal expression, persistent integrin-mediated activation in fibroblasts [45], excessive subchondral bone activity is linked to degeneration [44], and early overexpression predicting aggressive disease in PsA/RA [48]. The gene discussed is TGFB1; the disease is rheumatoid arthritis.