While the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed downregulation pathways, namely, viral myocarditis, and autoimmune conditions in both CD4+ and CD8+ Tg T cells of C57BL/6 mice, the gene sets important for heart contraction and cardiac muscle hypertrophy were negatively enriched, as analyzed by gene set enrichment analysis (GSEA) of Gene Ontology (GO) analysis. Here, CD8A is linked to viral myocarditis.