In this sense, transcriptomic and proteomic analyses performed in humans on gastrocnemius muscle biopsies from patients with PAD and control participants without PAD showed several enriched pathways, including those related to hypoxia, such as phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) signaling [65]. Here, WNK2 is linked to peripheral arterial disease.