RARB and lung carcinoma: Moreover, curcumin’s ability to downregulate DNMT3b mRNA levels contributes to the suppression of hTERT levels, as demonstrated in lung cancer cells, revealing a novel molecular pathway by which curcumin may act as a chemopreventive agent in lung cancer involving the reactivation of tumor suppressor genes such as RARβ, which ultimately impacts hTERT expression [71].