Inhibits PI3K/Akt/FoxO3a pathwayEnhances hypothalamic-pituitary-ovarian axisLowers hyperandrogenismDecreases LH/FSH ratio, enhances CYP19A1 and CYP11A1 expressionImproves insulin resistance in PCOS rats and restores the estrous cycle of rats. The gene discussed is FOXO3; the disease is polycystic ovary syndrome.