TIMP1 and interstitial lung disease: More MMP/TIMP (matrix metalloproteinase/tissue inhibitors of metalloproteinases) have demonstrated diagnostic utility in connective tissue disease-related ILD, particularly MMP-2, -7, -9, -10, -12 and TIMP-1, which, when analyzed in multi-marker panels, outperform single parameters in differentiating early fibrotic changes [36].