More intriguingly, whether as a writer like METTL3 and METTL14 or as an eraser like FTO and ALKBH5, all these are tumor promoting genes in melanoma, implying that the balance between methylation and demethylation in the tumor field needs to be precisely assessed, not only at an overall level but also accurately targeted to each specific gene. The gene discussed is ALKBH5; the disease is melanoma.