Our findings suggest that mTBI candidate genes such as APOE, S100B, GFAP, BDNF, AQP4, COMT, MBP, UCHL1, DRD2, ASIC1, and CACNA1A may have an essential role in lasting mTBI-related neurological disorders (gene functions detailed in Supplemental Materials). This evidence concerns the gene AQP4 and nervous system disorder.