Based on these criteria (i.e., neurological symptoms, cognitive impairment, recovery timeline and hub gene analysis), we were able to focus the mTBI list from 129 to 11 genes: APOE (Apolipoprotein E), S100B (s100 calcium binding protein B-), GFAP (Glial fibrillary acidic protein), BDNF (Brain-derived neurotrophic factor), AQP4 (Aquaporin-4), COMT (Catechol-O-methyltransferase), MBP (Myelin basic protein), UCHL1 (Ubiquitin C-terminal hydrolase L1), DRD2 (Dopamine receptor D2), ASIC1 (Acid-sensing ion channel 1), and CACNA1A (Calcium voltage-gated channel subunit alpha 1 A). This evidence concerns the gene AQP4 and Cognitive impairment.