MADCAM1 and Cirrhosis: MAdCAM-1 was expressed in tissue sections from 27/28 patients with cirrhosis, mainly localized in the endothelium of the peribiliary blood vessel plexus and in interstitial regions within lymphoid aggregates, and there was also a significant upregulation of MAdCAM-1 mRNA levels compared to the control group, which was consistent with immunohistochemical analysis [69].