CD8A and primary biliary cholangitis: A comprehensive phenotypic and functional characterization of CD8+ T cells in primary biliary cirrhosis concluded that CD45ROhigh CD57+ CD8high T cells are a subpopulation of cytotoxic memory cells that play a key role in the destruction of bile duct epithelial cells in PBC and that these cells have a higher α4β7 expression compared to other CD8high T cells [71].