Comparative proteomics of primary fibroblasts from IPF and systemic sclerosis (SSc) patients, using LC-MS combined with Tandem Mass Tag (TMT) labeling, revealed a shared ECM (matrisome) signature with overexpression of proteins such as PLOD2, LUM, POSTN, IGFBP5, GREM1, and SPARC [55], showing similar “fibrotic signatures” for IPF and SSc of activated myofibroblasts, mirroring the results of transcriptomic and miRNA data. This evidence concerns the gene IGFBP5 and idiopathic pulmonary fibrosis.