Among the ten genes, RETN [36,37], C3AR1 [38,39], CLCF1 [40], NTRK1 [41,42], OSMR [43], KCNN4 [44,45] and HTR7 [46] have established roles in cancer pathogenesis through regulating tumour growth, motility, angiogenesis, chemoresistance and immune evasion. The gene discussed is OSMR; the disease is cancer.