Moreover, a strong positive correlation was observed between the expression of C3AR1, CLCF1, OSMR, KCNN4 and HTR7 genes with the immune activator (e.g., IL1A, IL15, CCL2) and suppressor (e.g., TGFB1, IL6, IL10) genes (Figure 7A,B), suggesting a possible co-expression and/or co-regulation of these five genes with the immune-related genes in GBM. The gene discussed is IL6; the disease is glioblastoma.