ASOEA revealed that these genes are involved in regulating integrins-mediated cell–matrix interaction, RHO family GTPases- and FAK-signalling-induced cytoskeleton reorganisation, ECM remodelling and angiogenesis (Table 5; Table S12, Supplementary File S1), all of which are crucial for tumour cell migration and invasion. This evidence concerns the gene PTK2 and neoplasm.