Pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)—primarily secreted by macrophages and other immune cells in the TME—are instrumental in both tumor progression, systemic immune modulation, and renal function [64,65]. The gene discussed is IL6; the disease is neoplasm.