MAPT and Mental deterioration: Aβ42 is the main component of amyloid plaques, and current hypotheses suggest that lower CSF levels, as shown in this subgroup, suggest its aggregation in the brain [33].On top of that, a high amyloid burden enhances tau hyperphosphorylation, misfolding, and aggregation into neurofibrillary tangles, resulting in high tau levels, leading to neuronal death and cognitive decline [34].