Three clusters were identified: (1) Tau/CTRED-high group with limbic atrophy, (2) a volume-preserved group with low amyloid burden (high Aβ42) indicative of early disease stages, and (3) a Tau-focused, high amyloid (low Aβ42) group showing severe diffuse atrophy and ventriculomegaly. Here, MAPT is linked to Ventriculomegaly.